Hypertensive Nephropathy is a kind of kidney disorder caused by years of hypertension. Without timely treatment, it progresses to kidney failure which needs sufferers to do dialysis or kidney transplant. Similar with other kinds of kidney diseases, Hypertensive Nephropathy is easy to be ignored in the early stage, so many patients are diagnosed with advanced kidney disease once they found they are suffering kidney problem.
Long terms high blood pressure causes kidney problem easily. According to studies, Hypertensive Nephropathy occurs more easily among women than men. Usually, primary Hypertension tends to appear when people grow to 25 to 45, but symptoms of kidney damages caused by Hypertension appears when people grow to the age from 40 to 60.
Hypertension is such a common disease that many people do not take it seriously. Actually, short term high blood pressure hardly causes kidney problem; thereby, as long as Hypertension patients control their blood pressure actively, it is quite possible for them to avoid Hypertensive Nephropathy.
Hypertensive Nephropathy is a result of long-term persistent high blood pressure and it usually occurs after people suffer from Hypertension for 5 to 10 years. Therefore, for these people who has been diagnosed with Hypertension so many years, they should be alert about kidney problem. Well, since Hypertensive Nephropathy occurs because of Hypertension, how does high blood pressure affect our kidney?
As a matter of fact, Hypertension affects our kidney by damaging renal blood vessels. Our kidney is an internal organ which takes charge of filtering blood and of course blood flow into kidney through blood vessels. Therefore, in our kidneys, there are lots of large and small blood vessels. Hypertension refers to the condition that blood pressure in the arteries is elevated. With Hypertension, impact on vascular wall becomes large, which can damage our blood vessels directly. Long-term high blood pressure damages more and more renal blood vessels, as a result of which, kidney damage is formed and also Hypertensive Nephropathy can be caused.
In our body, compared with large blood vessels, these tiny renal blood vessels are damaged more easily. Therefore, in case of Hypertensive Nephropathy, damages of renal tubules usually occur firstly. Renal tubule has function to reabsorb nutrition and fluids that leaked from glomeruli. Therefore, once renal tubules are damaged, reabsorption decreases, leading to proteinuria and frequent urination.
Hypertension cause Hypertensive Nephropathy directly and in turn, Hypertensive Nephropathy also can cause renal hypertension directly. Therefore, for people with both high blood pressure and kidney problem, they need to find out the real relationship between their kidney problem and high blood pressure.
As the direct cause of Hypertensive Nephropathy, Hypertensive is also one of the dominant factors that can accelerate kidney problem to kidney failure. Therefore, no matter high blood pressure occurs before or after the diagnosis of kidney problem, keeping blood pressure into normal range is very beneficial.
Generally speaking, edema is the primary symptom that appears such as swollen eyelid or legs. And in serious cases, obvious swelling may occur in the whole body and when manual pressure is applied to a point on the body ,the depressin will occurs. Serious patients may be accompanied with such symptoms as pleural fluid,abdominal dropsy,and they may give rise to difficult breathing, exomphalocele or inguinal hernia. Heavy swelling is often accompanied with small amount of urine,high blood pressure and slight azotemia.
The most principal manifestationof hypertensive nephropathy is the massive albuminuria. For the adults, the everyday urine protein elimination is >=3.5g,and most of it is optional albuminuria.
The content of plasma proteins decreases, and serum albumin is less than 30g/L.seriously,much less than 10g/L.
Obvious increase of serum cholesterol and triglyceride can be observed easily and notably.
This symptom is commonly called blood urine by many people. In clinic, there are mainly two types of hematuria which refers to gross hematuria and microscopic hematuria. In comparison, microscopic hematuria is more common among people with kidney disease caused by Hypertension.
Gastrointestinal discomfort is not the typical complication of Hypertensive Nephropathy and it may occur among people with any kind of kidney
The blurred vison and evenretinal hemorrhage.
In different stage, people with hypertensive renal disease may experience different symptoms and in advanced stage, aside from the above symptoms, patients may also suffer from many other symptoms like itching skin, anemia and fatigue and hard breath and so on.
Whatever treatment is applied to the disease, western or Chinese, it achieves treatment efficacy through the following measures:
1) Vasodilatation: why we need vasodilatation? As once the immune complex starts to deposit in the glomerular capillary, all kinds of cells in the glomerular capillary will be short of blood and oxygen supply. Vasodilatation is to improve the blood circulation of kidneys and alleviate the ischemia and hypoxia of the cells of kidney so as to provide a good environment to restore the damaged mesangial cells.
2) Anti-inflammatory: the object of anti-inflammatory is to reduce the damages of inflammation to glomerular mesangial cells.
3) Anti-freezing: the increasing amount of inflammatory-cells in the blood will raise the consistency of the blood which results in an acceleration of the formation of micro-thrombus in the glomerular capillary. The usage of anticoagulant is to reduce the formation of micro-thrombus in order to lay the foundation for restoring the glomerular mesangial cells.
4) Degradation: the increased amount of inflammatory cells, micro-thrombus in blood vessel and immune complex depositing in the kidney will accumulate the deposit sediments and increase the amount of extracellular matrix in the endothelial cells, epithelium cells and mesangial cells of the glomerular capillary. As a result, relative medicine and treatments should be applied continuously to decompose the deposit sediments and extracellular matrix and excrete it out of body with the flow of urine.
On the basis of the abovementioned drugs, Chinese medicine and western medicine should be integrated perfectly to play the treatment efficacy into a full swing. With the proper application of the four treatment measures, the mesangial cells of glomerular capillary will be stored, so will other functions of kidneys. Once the barrier function of mesangial cells is recovery, the clinical symptoms including protein and occult blood will disappear for sure.
The treatment method of our hospital is different from the traditional ones. Traditional treatments usually focus on the control of clinical symptoms such as protein in urine and blood urine. However, the treatments of our hospital start from the treating of the very cause of such symptoms, which is, paying more attention on the restoring of endothelial cell,epithelial cell and the mesangial cell. The specific treatment is the comprehensive use of Vasodilatation, anti-inflammation, anti-freezing and degradation of toxic substances. In terms of medicine application, we have enhanced the use of the traditional Chinese medicine based on the western medicines and treatments and formulated some combine use plans. In addition, we have also developed a brand new therapy called Micro-Chinese medicine Osmotherapy to stop the renal fibrosis which has dramatically improved the treatment efficacy.
It is proved that Micro-Chinese medicine Osmotherapy dose have efficacy on restoring the glomerular mesangial cells. It is confirmed that once the damaged glomerular mesangial cells are restored, the condition will be improved, the improvement of condition will in turn promote the restore of glomerular mesangial cells and the protein and blood in urine will disappear subsequently. The condition is not likely to relapse with the above mentioned treatment.
Hypertensive Nephropathy refers to a type of chronic kidney disorder caused by poor controlling of high blood pressure. Kidney disease is a latent disease so people don't pose any evident symptom at initial stage. People with chronic hypertension should be regularly screened for kidney disease testing so as to detect early signs of renal damage and treat it as early as possible. The following will introduce on how is Hypertensive Nephropathy diagnosed so as to raise awareness about the disease.
Hypertensive Nephropathy as a secondary renal disease caused by high blood pressure most commonly occurs in those with hypertension history for five to ten years, and the onset age is at one's 40s to 50s. When kidneys get damaged by hypertension, the earliest sign of the disease would be nocturia, or increased night urination. Further kidney damage to the kidneys can cause proteinuria, and in some cases people experience intermittent gross hematuria. Hypertensive Nephropathy in its developing process is often combined with retinal arterial sclerosis, left ventricular hypertrophy, coronary disease, cerebral sclerosis, etc. So the disease tends to be more complicated than other types of kidney disorders.
Hypertensive Nephropathy can be diagnosed based on lab testings. Usually people are detected persistent and obviously elevated blood pressure, swelling in eyelids or lower limbs, dilated cardiac borders. Retinal arterial sclerosising lesion is detectable in many cases, and presence of fundus stripes, flame-shaped hemorrhage and cotton wool soft exudates will support the diagnosis of malignant renal arterial sclerosis. Those with accompanying hypertensive cerebral lesions may present corresponding nervous system physical signs. To support the diagnosis, some other lab tests may also be performed:
Urine microalbuminuria test. Hypertension can damage renal glomerular cells, so people may have an excess loss of albumin from urine. Microalbuminuria will detect early slight elevation of albumin in urine.
Urine sediment red blood cell counting. Urine sediment red blood cell counting suggests increased amount of red blood cells in urine, and most of the red blood cells are deformity.
Blood and urine beta-2 microglobulin testing. Beta-2 microglobulin testing us a sensitive indicator for glomerular filtration rate and renal tubular reabsorption functions. In early time, when kidneys are damaged moderately, beta-2 microglobulin levels in bloodstream can get elevated.
In early stage of the disease, people may experience increased levels of blood uric acid and increased levels of NAG. When hypertensive kidney disease progresses into end-stage, imaging test can detect obviously reduced kidney sizes. Other tests also include: electrocardiogram may suggest left ventricular high electric pressure, and chest X-ray or ultrasound may suggest main arterial sclerosis, left ventricular hypertrophy or enlargement.
The above introduces on the diagnosis of Hypertensive Nephropathy, hope it is of help for you. Anything unclear, you may contact us directly for free, and we'll be ready for help!